The Mind Matters – You’re Just Being Emotional

The Role of Hormones in Mental Health: Understanding the Connection

Welcome to the first edition of The Mind Matters with Rebekah G. Fayette, PMHNP. The signs of menopause are not just the super charged heater inside you telling you you’re in menopause. The role of hormones on your body also has an impact on mental well-being. Follow-us along this little emotional journey to understanding the connection on how changes in your body not only affect your physical self, but your mental well-being as well.

Let’s start with a discussion about hormones! These powerful chemical messengers are produced by various glands in the body, including the thyroid, adrenal glands, ovaries, and testes. They regulate a wide range of bodily functions, from metabolism and immune response to growth and reproduction. However, they also play a crucial role in mental health, affecting mood, cognition, behavior, and overall emotional stability.

You may be asking yourself; how do hormones affect the brain?

Hormones influence the brain's structure and function by interacting with neurotransmitters (chemicals that transmit signals between nerve cells). These interactions can directly influence how we feel, think, and behave. The fluctuations in hormone levels, whether due to stress, aging, or other factors, can lead to mental health challenges, including anxiety, depression, mood swings, and even more severe disorders like schizophrenia.

Key Hormones Involved in Mental Health

  • Cortisol is the body’s primary stress hormone, produced by the adrenal glands. Under normal circumstances, cortisol helps manage stress, control inflammation, and regulate metabolism. However, chronic stress can lead to consistently high cortisol levels, which can negatively affect the brain, impair memory, and contribute to anxiety and depression. Over time, prolonged cortisol imbalance may even lead to structural changes in the brain, particularly in areas like the hippocampus, which is crucial for memory and emotional regulation.

  • Serotonin is a neurotransmitter that plays a key role in mood regulation, sleep, appetite, and emotional balance. Often called the "feel-good" hormone, it contributes to feelings of happiness and well-being. Low serotonin levels are commonly associated with depression, anxiety, and mood disorders. Medications like selective serotonin reuptake inhibitors (SSRIs) work by increasing serotonin levels in the brain to alleviate symptoms of depression and anxiety.  I don’t know about you, but I feel good just talking about Serotonin levels!

  • Dopamine influences mood, motivation, and reward. Dopamine is known for inducing feelings of pleasure and satisfaction. Low levels of dopamine are linked to conditions such as depression, lack of motivation, and even addiction. Bipolar disorder is characterized by excessive levels of dopamine leading to mania (abnormally elevated mood with other hallmark features.)

  • Estrogen and progesterone are key hormones involved in the female reproductive system, though their impact extends far beyond reproduction. These hormones also affect mood, cognition, and mental health. Estrogen has a mood-enhancing effect and is believed to help regulate serotonin and dopamine levels, making it vital to mood stability. On the other hand, progesterone has a calming, even sedating effect, but can contribute to feelings of irritability or anxiety when levels fluctuate, particularly during the premenstrual phase (PMS) or during menopause.

    Did you know that a postmenopausal women has a lower level of estradiol than a man?

    During pregnancy, hormone levels fluctuate dramatically, which can lead to changes in mood and cognitive function, contributing to conditions like postpartum depression. Menopause, marked by a decrease in estrogen and progesterone, can also trigger mood swings, anxiety, and depression due to hormonal imbalances.

  • Testosterone is most often associated with male health, but it plays a significant role in mental health for both men and women. Yeah, that’s right!  Women need testosterone as well.  It is linked to energy, motivation, and mood. Low testosterone levels in men are associated with symptoms like fatigue, depression, irritability, and a lack of motivation. In women, low testosterone levels can lead to mood disturbances and a reduced sense of well-being.

  • The thyroid gland produces hormones that regulate metabolism and energy production in the body. An imbalance in thyroid hormones, whether hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), can have a direct impact on mental health. Hypothyroidism, for example, can lead to symptoms like fatigue, depression, and difficulty concentrating, while hyperthyroidism may cause anxiety, irritability, and even panic attacks.

Hormonal Changes and Mental Health Disorders

Hormonal changes are closely linked to several mental health disorders. When hormone levels are disrupted, it can lead to symptoms that mimic or contribute to the onset of conditions such as:
Depression: Often associated with low serotonin, dopamine, and estrogen levels, depression can also be worsened by cortisol imbalances. For women, hormonal shifts during PMS, pregnancy, or menopause can exacerbate feelings of sadness or hopelessness.
Anxiety: Cortisol, serotonin, and estrogen play significant roles in regulating anxiety. High cortisol levels and low serotonin can make individuals more susceptible to anxiety disorders.
Mood Swings: Hormonal fluctuations, particularly in estrogen and progesterone, are linked to mood swings. This is often seen during PMS, pregnancy, and menopause.
Postpartum Depression: After childbirth, the sudden drop in estrogen and progesterone levels can contribute to feelings of sadness and emotional instability, leading to postpartum depression.
Premenstrual Dysphoric Disorder (PMDD): A severe form of PMS, PMDD is characterized by extreme mood swings, irritability, anxiety, and depression. It is closely related to hormonal fluctuations, particularly estrogen and progesterone.

Managing Hormonal Influence on Mental Health

If you suspect that your mental health struggles are related to hormonal imbalances, it's important to seek medical advice. There are several ways to manage hormonal influence on mental health:
Medication: Hormone replacement therapy (HRT), antidepressants, or other medications may be prescribed to regulate hormones and alleviate symptoms.
Lifestyle Changes: Regular exercise, a balanced diet, stress management techniques (such as mindfulness or yoga), and adequate sleep can help balance hormones and improve mental health.
Therapy: Cognitive-behavioral therapy (CBT) and other forms of therapy can be beneficial in managing the psychological impact of hormonal changes.

Hormones play a significant role in shaping our mental health, influencing everything from mood to cognitive function. Recognizing the impact of hormonal imbalances on mental well-being is essential for understanding and addressing mental health challenges. With proper medical intervention and lifestyle adjustments, it is possible to achieve hormonal balance and improve overall mental health.

Many of us have had people say “You’re just being emotional!” While it may be true that we are emotional, it doesn’t mean we should ignore it, just hope it gets better on its own or let it define us. Don’t disregard your mental OR physical health. If you suspect that hormones may be affecting your mental health, consulting with a healthcare provider is the first step toward achieving stability and well-being.

Rebekah G. Fayette

My name is Rebekah G. Fayette. I am a board-certified Psychiatric Mental Health Nurse Practitioner (PMHNP) as well as a board-certified Nurse Midwife (CNM). I bring over two decades of experience as a registered nurse and a decade as a nurse practitioner. I have practiced my entire career here in the valley with a focus on caring for women of all cultural backgrounds through their pregnancies and postpartum care. I recently obtained my postgraduate with a focus on mental health and continue to serve women in an expanded capacity here in our state.

https://www.illuminationwh.com/rebekah-fayette
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